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» Osteosarcoma Study
 Posted: Oct 2 2010, 09:28 AM
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Grey Pup

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Dog disease research at Broad Institute

Now that we have the dog genome sequence, we are putting it to use. Our goal is to understand — and ultimately treat — the genetic causes of disease in dogs as well as their human companions.

How can your dog help?

This important research cannot proceed without the dog community's participation. We need DNA samples from purebred dogs suffering from the diseases we are studying (described below), as well as from older, healthy dogs from the breeds we are studying.

Current and future projects and our collaborators

Cancers: Cancer affects 30-50% of all dogs. A higher incidence in certain breeds suggests that genetic risk factors exist and can be identified. Many dog cancers are clinically similar to human cancers, including several that we are working on.

Osteosarcoma (bone cancer)

Osteosarcoma is the most common bone tumor of dog. This cancer develops in the bone, usually the limbs, and as the tumor grows it becomes progressively more painful for the dog and can result in lameness. Often these tumors metastasize to the lungs. Giant breeds are at the greatest risk for developing osteosarcomas.

Latest Research Update: To date, we have collected ~500 blood samples from dogs diagnosed with OSA and ~1500 healthy dogs over 8 years old. We have localized genetic risk factors that are associated with OSA to three chromosomal regions in greyhounds as well as three chromosomal regions in the Rottweiler breed, and are currently narrowing in on the precise mutations that cause the disease using ten different breeds. The biological effects of the mutations will be studied to better understand the cause and progression of the disease.
Breeds needed for our study: Rottweilers, Greyhounds, Mastiffs, Leonbergers, Golden Retrievers, Irish Wolfhounds, Great Pyrenees, Great Danes, Borzoi, and Scottish Deerhounds
Main collaborators: Kenine Comstock (The University of Michigan), Jaime Modiano (University of Minnesota), Cheryl London (Ohio State University), Elizabeth McNeil (Michigan State University), Matthew Breen (North Carolina State University)
Funding: AKC/CHF

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